Deadpool may be insufferable to the point of desperation due to his (almost) immortality, but there are ways to shut him up forever
The Merc with a Mouth may be the most annoying and insufferable thing in all of the multiverses. Several of his enemies (and allies) have openly pointed out that fighting him can be torture, even worse than death itself. Not only because he never closes his mouth and does incomprehensible things (breaking the fourth wall), ...